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Cockcroft-Gault Creatinine Clearance Calculator
The Cockcroft-Gault equation is the traditional standard for estimating creatinine clearance (CrCl) for renal drug dosing, and this calculator applies it directly: CrCl (mL/min) = [(140 − age) × weight in kg × (0.85 if female)] ÷ (72 × serum creatinine in mg/dL). For a 70-year-old man weighing 80 kg with a creatinine of 1.2 mg/dL, that gives (140 − 70) × 80 ÷ (72 × 1.2) = 5,600 ÷ 86.4 ≈ 64.8 mL/min; the same inputs for a woman give ≈ 55.1 mL/min after the 0.85 factor. Enter age, weight (lb or kg), sex and creatinine (mg/dL or µmol/L) to see CrCl with its general renal-dosing tier, and switch the weight basis to ideal or adjusted body weight for obese patients. Crucially, CrCl (Cockcroft-Gault) is for drug dosing and is not BSA-indexed, unlike eGFR, which is for CKD staging. This is an estimate for dose adjustment, not dosing advice — it is unreliable in acute kidney injury and a clinician decision. Free, private, and computed entirely in your browser.
CrCl = [(140 − age) × kg × (0.85 ♀)] ÷ (72 × Scr mg/dL) — Cockcroft-Gault, mL/min
- Worked example: 70 y, 80 kg, Scr 1.2 → ≈ 64.8 mL/min (male), ≈ 55.1 (female)
- Shown with ideal body weight and the general renal-dosing tier
Frequently asked questions
What is the Cockcroft-Gault formula for creatinine clearance?
CrCl (mL/min) = [(140 − age) × weight in kg × (0.85 if female)] ÷ (72 × serum creatinine in mg/dL). For a 70-year-old man weighing 80 kg with a creatinine of 1.2 mg/dL, that is 5,600 ÷ 86.4 ≈ 64.8 mL/min. It is the traditional standard for renal drug dosing and is not indexed to body surface area.
Is Cockcroft-Gault still used?
Yes — Cockcroft-Gault (1976) remains the reference equation for renal drug dosing because most pharmacokinetic studies and FDA/EMA drug labels are based on it. eGFR (CKD-EPI 2021) is preferred for staging chronic kidney disease, but for dose adjustment CrCl is still the standard. It is an estimate, not dosing advice — confirm with a clinician.